What is Caryophyllene? – What are its effects in cannabis?

What is Caryophyllene

Caryophyllene, also known as beta or b caryophyllene, is a terpene present in cannabis that has a herbal spiciness with woody undertones. Black pepper, cinnamon, and hops are the most prevalent sources. Caryophyllene is an anti-inflammatory salves and topicals ingredient with anticancer, antibacterial, antifungal, and antiseptic effects. After being ingested orally, caryophyllene has the ability to bind to CB2 cannabinoid receptors in the endocannabinoid system. Keeping up with Buy weed onlnine Potent Peak 

What is caryophyllene?

Notable as a dietary cannabinoid, the caryophyllene terpene is a frequent natural food additive. Shaded pale yellow, caryophyllene has a sweet taste found in such food items as allspice and fig. Caryophyllene is one of the most thoroughly studied terpenes found in cannabis. Organic chemist and Harvard researcher E. J. Corey studied caryophyllene in the 1960s and demonstrated the terpene’s unique properties. Corey’s pioneering research has aided contemporary scientists investigating caryophyllene’s potentially therapeutic uses.

What is caryophyllene used for?

Anyone who enjoys spicy foods is likely to have come into touch with caryophyllene at some stage. Caryophyllene can be found in a variety of foods, from cinnamon French toast to pepper steak. Caryophyllene, which is present in hops that flavor and stabilize beer, also possesses preservation characteristics. While beer is the most well-known beverage containing hops, it is far from the only one. Certain types of vodka and “hopped” whiskeys contain hops, and thus caryophyllene. Caryophyllene has also been utilized to enhance a lemony or spicy flavor profile in chewing gum. Detergents and a variety of topical skin treatments include the terpene.

What does caryophyllene smell like?


Caryophyllene has a strong, spicy, peppery scent, which it lends to essential oils with similar aroma profiles. Clove, basil, ylang ylang, rosemary, and black caraway are examples of caryophyllene-rich essential oils. Clove essential oil is notable for its numbing effect on pain, notably toothaches. Ylang-ylang essential oil, derived from a tropical tree native to India, is often integrated into perfumes as well as used in religious ceremonies in parts of Asia.

Therapeutic properties of caryophyllene

Many intriguing animal studies have been undertaken to identify diverse caryophyllene properties, most notably its potential therapeutic applications. More research is needed, however, to fully comprehend the impact of this terpene on human health, both physical and mental. Caryophyllene’s potential as an anticancer, antibacterial, and antioxidant agent was revealed in a 2015 study conducted on human cells and published in the journal Molecules. Although these findings are encouraging, more human study is needed to properly define caryophyllene’s medical applications.


Caryophyllene has been shown to have possible anti-inflammatory effects in ailments such as arthritis. One study, published in 2018 in the British Journal of Pharmacology, observed the response rate of the terpene’s anti-inflammatory properties in rats with induced arthritis. Researchers discovered that doses of 215 milligrams and 430 mg of caryophyllene given to both healthy and arthritic rats reduced the swelling of lymph nodes and did not modify the metabolism of the healthy rats.


Citing the need for further research, scientists have nonetheless hailed caryophyllene as reducing the growth and proliferation of cancer cells as well as enhancing the effectiveness of some cancer treatments according to a 2016 study published in the journal Cancer Medicine.


In combination with other terpenes, caryophyllene has shown promise as a sedative. A 2012 study published in the journal Pharmaceutical Biology found that mice treated with essential oil containing caryophyllene experienced increased sleep time as well as decreased locomotion and body temperature.


A 2013 study published in the European Journal of Pain found that when mice exposed to capsaicin were injected with caryophyllene, they experienced pain relief. The terpene was also found to enhance the pain-relieving properties of low doses of morphine.


When it comes to other potential beta-caryophyllene benefits, there is evidence indicating that the terpene, along with standard diabetic medicine, helps balance glucose levels in rats with diabetes, according to a 2014 study published in the journal Acta Histochemica.


There may be an exhaustive list of terpenes with the potential to ease anxiety, but caryophyllene, limonene, and myrcene are notable among them. Caryophyllene, in particular, was found in a 2014 study on mice to have therapeutic effects on anxiety and depression. The researchers, whose findings were published in the journal Physiology & Behavior, concluded that “the possibility that beta-caryophyllene may ameliorate the symptoms of these mood disorders offers exciting prospects for future studies.”

In addition, a 2016 study conducted on rats and published in the journal Molecular and Cellular Biochemistry showed that caryophyllene’s antioxidant and anti-inflammatory effects could potentially help with Parkinson’s disease. In a 2014 study published in the journal Pharmacology, caryophyllene was shown to reduce neuroinflammatory response in a mouse model of Alzheimer’s disease.

Role of caryophyllene in cannabis

Bubba Kush, OG Kush, Chemdawg, Sour Diesel, Rockstar, and Skywalker OG are among the cannabis types with high beta-caryophyllene levels. Caryophyllene is found in most cannabis strains, which is a fun fact.

Cannabis strains high in caryophyllene are thought to have a pain-relieving effect as a result of reduced inflammation. The terpene caryophyllene may have effects on short- and long-term brain health and mental well-being due to its affinity for CB2 receptors in the brain. Many cannabis topicals and salves include caryophyllene.

Bottom line

Caryophyllene, also known by its scientific name beta – caryophyllene, is commonly found in the culinary world and in cannabis, and it may help with inflammation.

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